Virtual Program

Virtual Program


Pathobiology That Drives Discovery, Diagnosis, and Treatment of Human Diseases: Present and Future



Monday - November 9, 2020

12:30 PM - 12:55 PM Welcome & Introductions
Cecelia Yates

Plenary Session: Revolutionary Thinkers

Cecelia Yates, PhD • University of Pittsburgh 
Richard Mitchell, MD, PhD • Brigham and Women's Hospital

This joint plenary session kicks off the PISA 2020 virtual meeting: “Pathobiology that Drives Discovery, Diagnosis, and Treatment of Human Diseases: Present and Future”. The goal of “Revolutionary Thinkers” is to present insights from world-class research innovators at the leading edge of molecular and cellular pathobiology.

Richard Mitchell
1:00 PM - 1:30 PM

Benjamin Ebert, MD, PhD • Dana-Farber/Harvard Cancer Center
“Therapeutic Targeting of Ubiquitin Ligases”

Dr. Ben Ebert is the Canellos Professor of Medicine at Harvard Medical School, Chair of Medical Oncology at the Dana-Farber Cancer Institute, a Howard Hughes Medical Institute Investigator, and an Institute Member of the Broad Institute; outside his scientific interests, Ben is also a competitive cyclist and triathlete. His lab works on projects varying from the somatic mutations that drive clonal hematopoiesis of indeterminant potential (CHIP; a term that his group coined) to the genetics, biology, and clinical implications of myelodysplastic syndromes. Dr. Ebert will highlight novel therapies targeting the machinery of ubiquitin ligases and proteasomal degradation in catabolizing disease-related proteins.

1:30 PM - 2:00 PM

Pardis Sabeti, MD, DPhil • Broad Institute
Outbreak Preemption and Response in the Genomic Age

Dr. Pardis Sabeti is a computational geneticist whose work focuses on developing algorithms to detect genetic signatures of adaption in microbial pathogens and their human hosts. She is a member of the Broad Institute, and a Howard Hughes Investigator Professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at the Harvard School of Public Health. She is also known as a rollerblading rock star scientist, was cited in 2015 as one of Time Magazine's 100 Most Influential people, and is the lead singer of the rock band Thousand Days. Dr. Sabeti will present an extremely topical discussion on the recognition and pre-emption of infectious disease outbreaks.

2:00 PM - 2:30 PM

George Church, PhD • Harvard Medical School
Free Whole Genomes and New Technologies for In-Situ Omics

Dr. George Church is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. In 2012, he co-authored Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves (the NewScientist called it the "top science book" of the year), and champions open education and citizen science for synthetic biology and personal genomics. His group has developed technologies to synthesize whole genes and engineer whole genomes—far faster, more accurately, and with less cost than current methods. As lead of Synthetic Biology at the Wyss Institute, he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Dr. Church will illustrate new genomic technologies that can help to facilitate the next generation of “omics” investigation.

2:30 PM - 2:45 PM Questions and Answers
2:45 PM - 3:00 PM Break

Symposia: Microglia: Dynamic and Complicated Players in Development and Disease

Christi Kolarcik, PhD • University of Pittsburgh
Warren Tourtellotte, MD, PhD • Cedars Sinai Medical Center

Session Description: Microglia are resident innate immune cells in the central nervous system that generally serve a protective role in mediating responses to infection.  They have additional diverse roles in synaptogenesis during development, synaptic integrity and turnover, neuronal support, and other injury repair processes.  In pathological conditions, the roles of microglia are even more complex with recent evidence that neuron-glia interactions affect a variety of cellular processes often with both positive and negative consequences.  In this session, we will discuss microglia dysfunction and neuroinflammation, explore the role of microglia as mediators or synapse loss, address disease-specific changes in the microglial sensome, and delve into complex regulatory mechanisms of microglia function in health and disease.

3:00 PM - 3:30 PM Joseph El Khoury, MD • Massachusetts General Hospital
Disease-specific Changes in the Microglial Sensome
3:30 PM - 4:00 PM Sebastien Werneburg, PhD • University of Massachusetts Medical School
Targeting Microglia-Mediated Synapse Elimination for Therapeutic Intervention in Demyelinating Disease
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers

Symposia: Novel Insights into Hepatobiliary Repair Via Reprogramming and Microbiome

Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh
Chad Walesky, PhD • Brigham and Women's Hospital/Harvard Medical School

Session Description: The term hepatobiliary injury encompasses a wide spectrum of diseases of the liver and biliary system, which can be caused by viral infections, alcohol, xenobiotic compounds, metabolic disorders, neoplasia, and autoimmune disorders, among others. Unfortunately, in many of these diseases, treatment is limited; thus, there is an urgent need to develop more effective therapeutic interventions. In this session, we will discuss the benefits of activating a cholangiocyte-like program in hepatocytes to promote biliary repair during cholestasis, explore the mechanism by which intestinal microbes protect against oxidative stress-induced liver injury, and investigate other novel mechanisms to ameliorate the pathophysiology of liver diseases.

Chad Walesky
3:00 PM - 3:30 PM Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh
“The Role of Wnt Signaling in Hepatocyte to Cholangiocyte Reprogramming”
3:30 PM - 4:00 PM Andrew Neish, MD • Emory University School of Medicine
“Microbiota-Derived Metabolites Regulate Hepatic Cytoprotection”
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers
6:00 PM Trainee Hangout

Tuesday - November 10, 2020

10:30 AM - 11:30 AM

Gene Expression Scientific Interest Group Meet-the-Experts Session Spatial Transcriptomics/Single Cell Analysis
Sponsored by the ASIP Gene Expression Scientific Interest Group

Rong Fan, PhD • Yale School of Engineering and Applied Science 
Title TBD

Robert Babak Faryabi, PhD • University of Pennsylvania 
Title TBD

11:00 AM - 12:30 PM Lunch Session: Lunch with the Stars
Sponsored by the ASIP Career Development and Diversity Committee and the ASIP Education Committee
12:30 PM - 1:00 PM TBD
Satdarshan (Paul) Monga

Plenary Session: Metabolism: From Organelles to Organisms

Satdarshan (Paul) Monga, MD • University of Pittsburgh
Jacqueline Russell, PhD • Boston Children's Hospital

Jacqueline Russell
1:00 PM - 1:30 PM Mary-Elizabeth Patti, MD • Joslin Diabetes Center, Inc.
Paternal Health and Intergenerational Transmission of Metabolic Disease Risk
1:30 PM - 2:00 PM David Cohen, MD, PhD • Weill Cornell Medicine
Non-Alcoholic Fatty Liver Disease
2:00 PM - 2:30 PM Bruce Spiegelman, PhD • Harvard Medical School/Dana-Farber Cancer Institute
Energy Metabolism and Adipose Tissue
2:30 PM - 2:45 PM Questions and Answers
2:45 PM - 3:00 PM Break
Dennis Jones

Symposia: Host Protection and Responses to Infectious Diseases

Dennis Jones, PhD • Boston University
Magali Saint-Geniez, PhD • Schepens Eye Research Institute

Session Description: Infectious diseases are a major cause of death and morbidity worldwide. To successfully prevent or target new, reemerging, and common infectious diseases, it is necessary to understand the complex relationships between pathogen and host. Collectively, the talks presented in this session will address key mechanisms used by viruses and bacteria to evade the host immune response. Recent advances in the understanding of host-pathogen interactions have yielded effective targets for vaccine and therapeutic intervention.

Magali Saint-Geniez
3:00 PM - 3:30 PM Frank DeLeo, PhD • National Institute of Allergy and Infectious Diseases
“Klebsiella Pneumoniae-Host Interactions”
3:30 PM - 4:00 PM Elke Mühlberger, PhD • Boston University School of Medicine
“The Inflammatory Response in Ebola Virus Infection”
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers
Pilar Alcaide

Symposia: Deconstructing the Vascular System: Multi-Scale Approaches

Pilar Alcaide, PhD • Tufts University School of Medicine
Guillermo Garcias-Cardeña, PhD • Harvard Medical School

Session Description: This Symposia will explore novel experimental approaches for studying the vascular system in health and disease, and discuss how these approaches have led to a better mechanistic understanding of several vascular pathologies including atherosclerosis and diabetes. Novel insights into vascular integrity and remodeling in disease settings will also be presented. Moreover, we will address how these multiscale approaches are driving the identification of new therapeutic target for diagnosis and treatment of cardiovascular disease.

Guillermo Garcias-Cardena
3:00 PM - 3:25 PM Joseph Aboleda-Valasquez, MD, PhD • Schepens Eye Research Institute
“Integrity of Vasculature in the Diabetic Environment”
3:25 PM - 3:50 PM Eno Ebong, PhD • Northeastern University
“Glycocalyx-Mediated Vascular Remodeling and Permeability in Disturbed Flow”
3:50 PM - 4:15 PM Yajaira Suarez, PhD • Yale University School of Medicine
“MicroRNA Regulation of Atherosclerosis”
4:15 PM - 4:25 PM Abstract-Driven Short Talk
4:25 PM - 4:35 PM Abstract-Driven Short Talk
4:35 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers

Wednesday - November 11, 2020

10:00 AM - 11:30 AM Breast Cancer Scientific Interest Group Meet-the-Expert Session
Celina Kleer, MD • University of Michigan 
"Understanding Breast Cancer: My Journey as a Physician Scientist"
10:00 AM - 11:30 AM Liver Pathobiology Scientific Interest Group Meet-the-Experts Session
Speaker: TBD
Patricia D'Amore

Plenary Session: Bench to Bedside: NOT Lost in Translation

Patricia D'Amore, PhD • Schepens Eye Research Institute/Harvard Medical School
Francis (Bill) Luscinskas, PhD • Brigham & Women's Hospital

Francis (Bill) Luscinskas
1:00 PM - 1:30 PM Joan Miller, MD • Massachusetts Eye & Ear Infirmary
“From Bench to Bedside: The Development of Anti-VEGF Therapy in Ophthalmology”
1:30 PM - 2:00 PM Christina Lockwood, PhD, DABCC, DABMGG • University of Washington
New and Emerging Opportunities and Consideration for Cell-Free DNA in Laboratory Medicine
2:00 PM - 2:30 PM

Mark Puder, MD, PhD • Boston Children's Hospital
Intestinal Failure Associated Liver Disease, A Laboratory and Clinical Approach

Many children are unable to tolerate or absorb nutrients and require intravenous nutrition (parenteral nutrition). Parenteral nutrition contains sugar, amino acids, lipids, vitamins and trace elements. This nutrition is life-saving, however up to 60% of infants develop intestinal failure associated liver disease (parenteral nutrition associated liver disease) that was responsible for 1.4% of all deaths in children age 4 years and under. This disease was one of the main indications for liver and multivisceral transplants in children. At the time, the actual component(s) of the parenteral nutrition producing the liver disease was unknown. We will discuss the laboratory experiments to understand the etiology (lipids) and the pathway to FDA approval of alternative lipid emulsions in treating this often fatal disease.

2:30 PM - 2:45 PM Questions and Answers
2:45 PM - 3:00 PM Break
Jennifer Sanders

Symposia: Not a Monolithic Disease: Cancer Heterogeneity and Precision Oncology

Jennifer Sanders, PhD • Brown University
Dipak Panigrahy, MD • Beth Israel Deaconess Medical Center

Session Description: Novel genetic and epigenetic changes in the tumor as well as the specific tissue microenvironment underlie the unique nature of tumor development, progression and response. Cancer therapy is challenging due to genetic heterogeneity of tumors, the diversity of pathways used by different tumors, and the relentless evolution of drug resistance. Nongenetic heterogeneity is also critical consideration as cells respond to broad, environmental perturbations and drug treatments. Big data technologies have expanded our abilities to characterize and model individual tumor and patient responses. In this symposium, we will discuss the contribution and mechanisms by which differences in the tumor and host genome, epigenome and tumor microenvironment regulate tumor evolution and individual patient response to therapy. We will also delve into how the knowledge generated by big data combined with artificial intelligence and machine learning approaches can lead to advances in more precise diagnostic and therapeutic options for patients.

Dipak Panigrahy
3:00 PM - 3:30 PM Jennifer van't Veer, PhD • University of California, San Francisco
“Matching Targeted Therapies to the Biology of Disease in Breast Cancer”
3:30 PM - 4:00 PM Franziska Michor, PhD • Harvard University
“Spatial Intra-Tumor Heterogeneity is Associated with Survival of Lung Adenocarcinoma Patients”
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers
James Stone

Symposia: And the Beat Goes On: New Wrinkles in Cardiovascular Pathophysiology

James Stone, MD, PhD • Massachusetts General Hospital
Traci Parry, PhD • University of North Carolina at Greensboro

Session Description: This symposium will cover two important and evolving topics in cardiovascular pathophysiology, the genetics of sudden death and the role of inflammation in atherosclerosis.  Sudden unexpected cardiac death strikes without warning, killing both young and old. While some genetic variants have long been associated with sudden cardiac death, the wider application of whole genome sequencing in those who experience sudden cardiac death is opening up new avenues for research into this phenomenon; but it is also creating complexities into understanding the true pathogenicity of newly identified genetic variants.  Atherosclerosis remains a leading cause of death world-wide. Through both animal modelling and human studies inflammation promoted by interleukin-1 has been identified as a key driver of this pervasive condition.  A detailed understanding of the inflammatory response in the vessel wall during atherogenesis offers the potential for the development of novel and selective approaches to treat this deadly condition. 

Traci Parry
3:00 PM - 3:30 PM Heidi Rehm, PhD • Broad Institute/Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical School
“Curating the Clinical Genome on a Global Scale”
3:30 PM - 4:00 PM Peter Libby, MD • Brigham & Women's Hospital and Harvard Medical School
“Interleukin-1 in Atherosclerosis: A Translational Journey”
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers

Thursday - November 12, 2020

10:00 AM - 11:00 AM Session Information Pending
11:00 AM - 12:30 PM

Lunch Session: Pathology Career Pathway Networking
Sponsored by the ASIP Career Development and Diversity Committee and the ASIP Education Committee

12:30 PM - 1:00 PM Session Information Pending

Plenary Session: Computational Pathology: Big Data, Big Ideas Translation

Jeffrey Golden, MD • Brigham & Women's Hospital
Lynn Bry, MD, PhD • Brigham & Women's Hospital

Session Description: Big data has referred to the means to acquire and analyze new, complex and multi-dimensional sources of information. Novel tools to extract meaning from ‘big data’ have the potential to drive substantive changes in clinical practice, from personalized diagnostics, prognostics and therapeutics to intelligent drug design, population surveillance/screening and the mining of the electronic health record. Successful integration of data analytics and data sciences within platforms for biomedical discovery are expanding further innovations and applications to patient care. 

In this symposium we will explore underlying principles of big data approaches, and the translation of findings to clinical applications. Discussions will explore three examples of integrated ‘big data’ and functional discovery approaches, (1) digital imaging and improved pathologic diagnosis, (2) pathogen and microbiome big data approaches to identify new therapeutic targets and implement better prevention methods for pathogens from C. difficile to COVID-19, and (3) single cell sequencing to define genomic and environmental drivers of cancer, and identify targets for new therapeutic approaches. These examples will provide insights into how computational pathology is developing the tools we will be using to care for patients in the future. 

1:00 PM - 1:30 PM Andrew Beck, MD, PhD • PathAI
AI and Pathology Imaging
1:30 PM - 2:00 PM Lynn Bry, MD, PhD • Harvard Medical School/Brigham and Women's Hospital
Microbiome and Applications of Big Data
2:00 PM - 2:30 PM Mario Suva, MD, PhD • Harvard Medical School/Massachusetts General Hospital
Dissecting Brain Tumors by Single-Cell Genomics
2:30 PM - 2:45 PM Questions and Answers
2:45 PM - 3:00 PM Break

Symposia: New Horizons for Neutrophils and Monocytes in Mucosal and Vascular Cell Biology

Asma Nusrat, MD • University of Michigan
Francis (Bill) Luscinskas, PhD • Brigham & Women's Hospital

Session Description: Monocytes and neutrophils play key roles in the pathogenesis of many diseases. Monocytes undergo a continuum of phenotypic and functional changes in response to inflammatory cues.  The first presentation identified mechanisms that drive monocyte to macrophage differentiation in glomerulonephritis, an autoimmune disease of the kidney. Leukocyte adhesion and migration requires rapid actin dynamics. The second presentation studied the function of the cortactin homologue HS1 in neutrophils using two different murine models: intravital microscopy of the inflamed cremaster microcirculation and experimental colitis.

3:00 PM - 3:30 PM Tanya Mayadas, PhD • Brigham and Women's Hospital
Molecular Control of Monocyte Maturation During Inflammation
3:30 PM - 4:00 PM Michael Schnoor, PhD • Centro de Investigacion y de Estudios (CINVESTAV) 
"The Actin-Binding Protein HS1 Regulates Neutrophil Recruitment Patterns During Inflammation"
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers
Gregory Tsongalis

Symposia: Molecular Diagnostics: The Liquid Biopsy

Gregory Tsongalis, PhD • Dartmouth-Hitchcock Health System
D. Hunter Best, PhD, FACMG • University of Utah

D. Hunter Best
3:00 PM - 3:30 PM John Iafrate, MD • Massachusetts General Hospital
ctDNA: Practical Realities and Future Applications" 
3:30 PM - 4:00 PM Joshua F. Coleman, MD • ARUP Laboratories
"Liquid Biopsy: Emerging Applications for Solid Tumors"
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers

Friday - November 13, 2020

10:00 AM - 1:00 PM Session information Pending
Elizabeth Whitley

Plenary Session: Architectural Models of Disease: Rendering Complexity on a Small Scale

Elizabeth Whitley, DVM, PhD • University of Texas MD Anderson Cancer Center
Arlin Rogers, DVM, PhD • Alnylam Pharmaceuticals

Session Description: Experimental models allow empirical research in physiologic and pathophysiologic processes. In this symposium, we highlight innovative models that deliver high levels of complexity that allow of dissection and modification of complicated, interactive biological systems, while also providing measures of efficiency and affordability and addressing the three “Rs” tenet of animal modeling (Replacement, Reduction, and Refinement). The first presentation of this symposium will focus on the emerging use of Zebrafish as vertebrate models for metabolic and neoplastic diseases of the liver and pancreas. The second presentation will delve into molecular mechanisms that modify the hallmark traits of aging and result in vast differences in lifespan across rodent species. The third presentation will describe stem cell engineering strategies for in vitro manufacture of mature, functional populations of blood components for preclinical studies and eventual clinical use. 

Arlin Rogers
1:00 PM - 1:30 PM Wolfram Goessling, MD, PhD • Harvard Stem Cell Institute
“Title Pending”
1:30 PM - 2:00 PM Vera Gorbunova, PhD • University of Rochester
Mechanisms of Longevity in Naked Mole Rats and Other Long-Lived Rodents
2:00 PM - 2:30 PM George Daley, MD, PhD • Harvard Medical School/Children's Hospital Boston
Blood From a Petri Dish
2:30 PM - 2:45 PM Questions and Answers
2:45 PM - 3:00 PM Break
Pilar Alcaide

Symposia: Host-Microbial Interactions at the Mucosal Surfaces

Pilar Alcaide, PhD • Tufts University School of Medicine
Andrei Ivanov, PhD • Cleveland Clinic Foundation

Session Description: Mucosal epithelia create critical interfaces and protective barriers to interact with commensal microbes and prevent pathogen invasion. This symposium will present recent advances in understanding the mechanisms that regulate host-microbial cross-talk at different mucosal surfaces. The first talk will be dedicated to local immune mechanisms that protect against HIV in the female genital tract, with specific focus on neutrophils and neutrophil extracellular traps. The second talk will be focused on the intestinal mucosa and will describe the roles of natural killer T (NKT) cells in regulating gut microbial commensalism and response to pathogens.  Age dependent and microbiome dependent mechanisms of NKT cell regulation will also be discussed. 

Andrei Ivanov
3:00 PM - 3:30 PM Marta Rodriguez-Garcia, MD, PhD • Tufts University School of Medicine
“The Role of Neutrophils in HIV Prevention in the Female Genital Tract”
3:30 PM - 4:00 PM Richard "Rick" Blumberg, MD • Brigham and Women's Hospital/Harvard
“NKT Cells at the Mucosal Interface
4:00 AM - 4:15 PM Abstract-Driven Short Talk
4:15 AM - 4:30 PM Abstract-Driven Short Talk
4:30 AM - 4:45 PM Abstract-Driven Short Talk
4:45 AM - 5:00 PM Questions and Answers
Diane Bielenberg

Symposia: Lymphatic Biology, Obesity, and Beyond

Diane Bielenberg, PhD • Boston Children's Hospital
Yang Lee, PhD, MS, BS • Boston Children's Hospital/Harvard Medical School

3:00 PM - 3:30 PM Hong Chen, PhD • Harvard Medical School/Boston Children's Hospital
“Mechanisms of Foxc2-Mediated Regulation of Lymphatic Function in Metabolic Diseases”
3:30 PM - 4:00 PM Anne Eichmann, PhD • Yale University School of Medicine
“Lacteal Junctions as Regulators of Plasma Lipid Uptake and Obesity”
4:00 PM - 4:15 PM Abstract-Driven Short Talk
4:15 PM - 4:30 PM Abstract-Driven Short Talk
4:30 PM - 4:45 PM Abstract-Driven Short Talk
4:45 PM - 5:00 PM Questions and Answers