Virtual Program - Meeting Registration Grants You Access to ALL Sessions and Activities

Virtual Program - Meeting Registration Grants You Access to ALL Sessions and Activities


Pathobiology That Drives Discovery, Diagnosis, and Treatment of Human Diseases: Present and Future

Session Times are EST


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Monday - November 9, 2020

12:30 PM - 1:00 PM (EST) Welcome & Introductions
Cecelia Yates

Plenary Session: Revolutionary Thinkers

Cecelia Yates, PhD • University of Pittsburgh 
Richard Mitchell, MD, PhD • Brigham and Women's Hospital

This joint plenary session kicks off the PISA 2020 virtual meeting: “Pathobiology that Drives Discovery, Diagnosis, and Treatment of Human Diseases: Present and Future”. The goal of “Revolutionary Thinkers” is to present insights from world-class research innovators at the leading edge of molecular and cellular pathobiology.

Richard Mitchell
1:00 PM - 1:30 PM (EST)

Benjamin Ebert, MD, PhD • Dana-Farber/Harvard Cancer Center
“Therapeutic Targeting of Ubiquitin Ligases”

Dr. Ben Ebert is the Canellos Professor of Medicine at Harvard Medical School, Chair of Medical Oncology at the Dana-Farber Cancer Institute, a Howard Hughes Medical Institute Investigator, and an Institute Member of the Broad Institute; outside his scientific interests, Ben is also a competitive cyclist and triathlete. His lab works on projects varying from the somatic mutations that drive clonal hematopoiesis of indeterminant potential (CHIP; a term that his group coined) to the genetics, biology, and clinical implications of myelodysplastic syndromes. Dr. Ebert will highlight novel therapies targeting the machinery of ubiquitin ligases and proteasomal degradation in catabolizing disease-related proteins.

1:30 PM - 2:00 PM (EST)

George Church, PhD • Harvard Medical School
Free Whole Genomes and New Technologies for In-Situ Omics

Dr. George Church is Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and MIT. He is Director of the U.S. Department of Energy Technology Center and Director of the National Institutes of Health Center of Excellence in Genomic Science. In 2012, he co-authored Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves (the NewScientist called it the "top science book" of the year), and champions open education and citizen science for synthetic biology and personal genomics. His group has developed technologies to synthesize whole genes and engineer whole genomes—far faster, more accurately, and with less cost than current methods. As lead of Synthetic Biology at the Wyss Institute, he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Dr. Church will illustrate new genomic technologies that can help to facilitate the next generation of “omics” investigation.

2:00 PM - 2:30 PM (EST)

Pardis Sabeti, MD, DPhil • Broad Institute
Outbreak Preemption and Response in the Genomic Age

Dr. Pardis Sabeti is a computational geneticist whose work focuses on developing algorithms to detect genetic signatures of adaption in microbial pathogens and their human hosts. She is a member of the Broad Institute, and a Howard Hughes Investigator Professor at the Center for Systems Biology and Department of Organismic and Evolutionary Biology at Harvard University and the Department of Immunology and Infectious Disease at the Harvard School of Public Health. She is also known as a rollerblading rock star scientist, was cited in 2015 as one of Time Magazine's 100 Most Influential people, and is the lead singer of the rock band Thousand Days. Dr. Sabeti will present an extremely topical discussion on the recognition and pre-emption of infectious disease outbreaks.

2:30 PM - 2:45 PM (EST) Questions and Answers
2:45 PM - 3:00 PM (EST) Break

Symposia: Microglia: Dynamic and Complicated Players in Development and Disease

Warren Tourtellotte, MD, PhD • Cedars Sinai Medical Center
Christi Kolarcik, PhD • University of Pittsburgh

Session Description: Microglia are resident innate immune cells in the central nervous system that generally serve a protective role in mediating responses to infection.  They have additional diverse roles in synaptogenesis during development, synaptic integrity and turnover, neuronal support, and other injury repair processes.  In pathological conditions, the roles of microglia are even more complex with recent evidence that neuron-glia interactions affect a variety of cellular processes often with both positive and negative consequences.  In this session, we will discuss microglia dysfunction and neuroinflammation, explore the role of microglia as mediators or synapse loss, address disease-specific changes in the microglial sensome, and delve into complex regulatory mechanisms of microglia function in health and disease.

3:00 PM - 3:30 PM (EST) Joseph El Khoury, MD • Massachusetts General Hospital
Disease-Specific Changes in the Microglial Sensome
3:30 PM - 4:00 PM (EST) Sebastian Werneburg, PhD • University of Massachusetts Medical School
Targeting Microglia-Mediated Synapse Elimination for Therapeutic Intervention in Demyelinating Disease
4:00 PM - 4:15 PM (EST)

Abstract-Driven Short Talk
Lokman Cevik
- "Comparison of Different Segmentation Methods in OLIG2 Stained Low-Grade Glioma Images"


4:15 PM - 4:30 PM (EST)

Amir Raeisi NafchiAbstract Driven Short Talk
Amir Raeisi Nafchi - "The Correlations Between Autophagy and Herpesvirus and Their Interactions to Neurodegeneration in Alzheimer’s Disease"


4:30 PM - 4:45 PM (EST)

Abstract-Driven Short Talk
Adwitia Dey - "The Role of Long-Chain Fatty Acid Elongases in α-Synuclein Associated Neuropathology"


4:45 PM - 5:00 PM (EST) Questions and Answers

Symposia: Novel Insights into Hepatobiliary Repair Via Reprogramming and Microbiome

Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh
Chad Walesky, PhD • Brigham and Women's Hospital/Harvard Medical School

Session Description: The term hepatobiliary injury encompasses a wide spectrum of diseases of the liver and biliary system, which can be caused by viral infections, alcohol, xenobiotic compounds, metabolic disorders, neoplasia, and autoimmune disorders, among others. Unfortunately, in many of these diseases, treatment is limited; thus, there is an urgent need to develop more effective therapeutic interventions. In this session, we will discuss the benefits of activating a cholangiocyte-like program in hepatocytes to promote biliary repair during cholestasis, explore the mechanism by which intestinal microbes protect against oxidative stress-induced liver injury, and investigate other novel mechanisms to ameliorate the pathophysiology of liver diseases.

Chad Walesky
3:00 PM - 3:30 PM (EST) Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh
“The Role of Wnt Signaling in Hepatocyte to Cholangiocyte Reprogramming”
3:30 PM - 4:00 PM (EST) Andrew Neish, MD • Emory University School of Medicine
“Microbiota-Derived Metabolites Regulate Hepatic Cytoprotection”
4:00 PM - 4:15 PM (EST)

Abstract-Driven Short Talk
Anders Ohman - "Harnessing the Fetal Hepatocyte Proliferative Phenotype to Improve Liver Cell Transplantation"


4:15 PM - 4:30 PM (EST)

Abstract-Driven Short Talk
Daniel Shao - "Loss of β-catenin Increases α-Naphthylisothiocyanate-Induced Mortality and Cholestatic Liver Injury"


4:30 PM - 4:45 PM (EST)

Evan DelgadoAbstract-Driven Short Talk
Evan Delgado - "Overexpression of the Scaffolding Protein IQGAP1 Promotes Hepatocellular Carcinoma by Activating YAP1 Signaling"


4:45 PM - 5:00 PM (EST) Questions and Answers
5:00 PM - 6:00 PM Break (View the ePosters)
6:00 PM - 8:00 PM (EST)

Trainee Hangout

A virtual meeting can be difficult to navigate, especially as a trainee. PISA2020 offers a variety of opportunities to expand your professional network and to learn from a wide variety of professionals. In this session we will help trainees navigate the virtual meeting interface and cover exciting opportunities, such as education sessions, advertising yourself, and our special Meet-the-Expert session! This session will be moderated by senior trainee members of the ASIP and will ensure you will be able to have the best virtual conference experience!

Session Moderators:

Morgan Preziosi, PhD
Chimeron Bio

Roberto Mota Alvidrez, MD, MS
Research Assistant Professor University of Pittsburgh
University of Pittsburgh

Alexander Sougiannis, PhD
Medical Student
Medical University of South Carolina

Tuesday - November 10, 2020

9:00 AM - 10:00 AM (EST)

Trainee Advising Session

Gregory J. Tsongalis, PhD • Dartmouth-Hitchcock Health System
Living the Best of Both Worlds: Translating Science into Clinical Practice
This session will describe careers in the clinical/molecular diagnostic laboratories for PhD-trained scientists. PhD scientists working in the clinical setting perform sophisticated molecular tests, interpret results of these test to advise clinicians in the treatment of patients, and develop new molecular tests for various diagnostic applications. This session will be of interest to undergraduates, graduate/medical students, or postdoctoral fellows.

Qin Yan

Gene Expression Scientific Interest Group
Meet-the-Experts Session: Spatial Transcriptomics/Single Cell Analysis

Sponsored by the ASIP Gene Expression Scientific Interest Group

Session Moderators:
Qin Yan, PhD • Yale University
Philip Iannaccone, MD, PhD • Northwestern University Medical School
David Williams, MD, PhD • University of North Carolina

David Williams Philip Iannaccone
10:00 AM - 10:30 AM (EST) Rong Fan, PhD • Yale School of Engineering and Applied Science 
"Spatial Omics Sequencing at the Cellular Level" 
10:30 AM - 11:00 AM (EST) Robert Babak Faryabi, PhD • University of Pennsylvania
“Alternative Perspectives to Multi-Omics Single-Cell Analysis” 
11:00 AM - 11:30 AM (EST) Questions and Answers
11:00 AM - 12:30 PM (EST)

Lunch Session: Lunch with the Stars
Sponsored by the ASIP Career Development and Diversity Committee and the ASIP Education Committee

Pilar Alcaide, PhD
Tufts University School of Medicine

Patricia D'Amore, PhD
Schepens Eye Research Institute/Harvard Medical School

Andrew Duncan, PhD
University of Pittsburgh

Andrew Duncan

Christi Kolarcik, PhD
University of Pittsburgh

William Muller, MD, PhD
Northwestern University

Kari Nejak-Bowen, PhD, MBA
University of Pittsburgh

Magali Saint-Geniez, PhD
Schepens Eye Research Institute/Harvard Medical School

Ronen Sumagin, PhD
Northwestern University

Xiao-Ming Yin, MD, PhD
Tulane University

Elaine Bearer, MD, PhD, FAAAS, FCAP
University of New Mexico Health Sciences Center

Wen-Xing Ding PhD, FAASLD
University of Kansas

Martha Furie, PhD
Stony Brook University

Richard Mitchell, MD, PhD
Brigham and Women's Hospital

James Musser, MD, PhD
Houston Methodist Hospital

George Perry, PhD
University of Texas at San Antonio

Jennifer Sanders, PhD
Brown University

Qin Yan, PhD
Yale University School of Medicine

Qing Zhang, PhD
UT Southwestern Medical School

12:30 PM - 1:00 PM (EST) Break (View the ePosters)
Satdarshan (Paul) Monga

Plenary Session: Metabolism: From Organelles to Organisms

Satdarshan (Paul) Monga, MD • University of Pittsburgh
Jacquelyn Russell, PhD • Boston Children's Hospital

Session Description: Metabolic homeostasis is key to health, and perturbations in metabolism are central to the pathogenesis of several diseases. The session “Metabolism: From Organelles to Organisms” will touch upon not only the key and timely aspects of the mechanisms that are the basis metabolic homeostasis but also how specific aberrations can have diverse pathological consequences. The world-renowned faculty will share their recent work on impact of parental health, environment and lifestyle on the health of offspring with an emphasis on metabolic consequences through epigenetic regulation. Likewise, the impact of thermogenesis in response to cold temperatures on energy expenditure and how it may have relevance in obesity related disorders such as non-alcoholic fatty liver disease, will be discussed. Similarly, how master transcriptional regulators like PGC1a, critical in regulating mitochondrial biogenesis and oxidative metabolism, control the metabolic programs in many tissues including muscle, will be discussed. All the speakers will also discuss the relevance of targeting key molecules for potential therapies.

Jacqueline Russell
1:00 PM - 1:30 PM (EST)

Mary-Elizabeth Patti, MD • Joslin Diabetes Center, Inc.
Paternal Health and Intergenerational Transmission of Metabolic Disease Risk

Emerging evidence indicates that parental health can influence the health of offspring via both traditional genetic factors (DNA sequence) as well as via environmental factors such as lifestyle, nutrition, and activity levels. The impact of environmental factors may be particularly important if experienced during development (i.e. during intrauterine life) or during early childhood. These same environmental exposures can also influence developing germ cells – thus generating a potential vicious cycle of intergenerational risk of disease. While many individuals are familiar with the concept that maternal health is a key influence on child health, emerging data also demonstrate that the father’s health can also influence the sperm epigenome and thus contribute to offspring health.

1:30 PM - 2:00 PM (EST) David Cohen, MD, PhD • Weill Cornell Medicine
Towards New Molecular Targets for Non-Alcoholic Fatty Liver Disease: Phospholipid-Mediated Regulation of Hepatic Lipid and Glucose Metabolism
2:00 PM - 2:30 PM (EST) Bruce Spiegelman, PhD • Harvard Medical School/Dana-Farber Cancer Institute
Energy Metabolism and Adipose Tissue
2:30 PM - 2:45 PM (EST) Questions and Answers
2:45 PM - 3:00 PM (EST) Break
Dennis Jones

Symposia: Host Protection and Responses to Infectious Diseases

Dennis Jones, PhD • Boston University
Magali Saint-Geniez, PhD • Schepens Eye Research Institute

Session Description: Infectious diseases are a major cause of death and morbidity worldwide. To successfully prevent or target new, reemerging, and common infectious diseases, it is necessary to understand the complex relationships between pathogen and host. Collectively, the talks presented in this session will address key mechanisms used by viruses and bacteria to evade the host immune response. Recent advances in the understanding of host-pathogen interactions have yielded effective targets for vaccine and therapeutic intervention.

Magali Saint-Geniez
3:00 PM - 3:30 PM (EST) Frank DeLeo, PhD • National Institute of Allergy and Infectious Diseases
“Klebsiella Pneumoniae-Host Interactions”
3:30 PM - 4:00 PM (EST) Elke Mühlberger, PhD • Boston University School of Medicine
“The Inflammatory Response in Ebola Virus Infection”
4:00 PM - 4:15 PM (EST)

Diana ToledoAbstract-Driven Short Talk
Diana Toledo - "Regional COVID-19 Virus Evaluation in Recrement (RECOVER) Project for Wastewater-Based SARS-CoV-2 Surveillance in Northern New England"


4:15 PM - 4:30 PM (EST)

Thibault AllainAbstract-Driven Short Talk
Thibault Allain - "Short Term Consumption of Western Diet Increases the Severity of Giardia Infection in Association with Gut Microbiota Dysbiosis"


4:30 PM - 4:45 PM (EST)

Abstract-Driven Short Talk
Sungjin Ko - "Highly Efficient Single-Domain Antibody Neutralization of Interleukin-6, the Factor at the Epicenter of Cytokine Storm in Acutely Ill COVID-19 Patients"


4:45 PM - 5:00 PM (EST) Questions and Answers
Pilar Alcaide

Symposia: Deconstructing the Vascular System: Multi-Scale Approaches

Pilar Alcaide, PhD • Tufts University School of Medicine
Guillermo Garcias-Cardeña, PhD • Harvard Medical School

Session Description: This Symposia will explore novel experimental approaches for studying the vascular system in health and disease, and discuss how these approaches have led to a better mechanistic understanding of several vascular pathologies including atherosclerosis and diabetes. Novel insights into vascular integrity and remodeling in disease settings will also be presented. Moreover, we will address how these multiscale approaches are driving the identification of new therapeutic target for diagnosis and treatment of cardiovascular disease.

Guillermo Garcias-Cardena
3:00 PM - 3:25 PM (EST) Joseph Arboleda-Velasquez, MD, PhD • Schepens Eye Research Institute
“Integrity of Vasculature in the Diabetic Environment”
3:25 PM - 3:50 PM (EST) Eno Ebong, PhD • Northeastern University
“Glycocalyx-Mediated Vascular Remodeling and Permeability in Disturbed Flow”
3:50 PM - 4:15 PM (EST) Yajaira Suarez, PhD • Yale University School of Medicine
“MicroRNA Regulation of Atherosclerosis”
4:15 PM - 4:25 PM (EST)

Abstract-Driven Short Talk
Roberto Mota Alvidrez - "Longitudinal In Vivo Atherosclerotic Disease Development in the apoE Deficient Zucker Rat"


4:25 PM - 4:35 PM (EST)

Sathish VasamsettiAbstract-Driven Short Talk
Sathish Vasamsetti - "Heart Failure Induced Insulin Resistance Is Associated With Decreased Adipokines Production: Role of Impaired Adipogenesis"


4:35 PM - 4:45 PM (EST)

Abstract-Driven Short Talk
Yao Gao - "Semaphorin-3F Inhibits Vascular Permeability During Acute Inflammation"


4:45 PM - 5:00 PM (EST) Questions and Answers
5:00 PM - 6:00 PM (EST) Break (View the ePosters)
6:00 PM - 8:00 PM (EST)

Women in Pathology (WiP) "Jeopardy"

The pandemic has detrimentally impacted mental health and wellness as career and home workloads expanded. Join us for a fun break to learn more about Women in Pathology and about the history of women in the ASIP. This is not just for women! Men, please show your support for this blooming group of amazing women while you have fun and a chance to win prizes! Don't miss this networking opportunity for a vivid discussion and game!

Session Moderators:

Linda McManus, PhD
University of Texas Health Science Center

Pilar Alcaide, PhD
Tufts University

Nakisha Rutledge, BSC
Northwestern University


Wednesday - November 11, 2020

8:00 AM - 9:00 AM (EST)

Trainee Advising Session

Richard N. Mitchell, MD, PhD • Brigham & Women's Hospital
Considering Medical School
Individuals who are interested in disease might pursue basic science research training (in graduate school) and/or clinical training in medical school. Medical school training provides students with an understanding of pathology, pathogenesis, and pathophysiology with a focus on patient care. It is not uncommon for PhD-trained scientists to pursue medical school to complete their training in pursuit of a career in translational research. This session will be of interest to undergraduates, graduate students, or postdoctoral fellows.

9:00 AM - 10:00 AM (EST)

Trainee Advising Session

Traci L. Parry, PhD • University of North Carolina at Greensboro
Individual Development Plans (IDPs) for Trainees: Your Plan for Success
To achieve success in a career focused on biomedical research, you need a plan. Individual development plans (IDPs) are now encouraged for individuals at all stages of career and when carefully constructed can lead to successful outcomes trainees and non-trainees alike. However, IDPs are critical for trainees and this session will outline how to develop a robust IDP to guide individuals moving through training. This session will be of interest to undergraduates, graduate/medical students, or postdoctoral fellows.

Chhavi Chauhan

Breast Cancer Scientific Interest Group Meet-the-Expert Session

Session Moderators:
Chhavi Chauhan, PhD, ELS • American Society for Investigative Pathology
Bethany Hannafon, PhD • University of Oklahoma Health Sciences Center

Bethany Hannafon
10:00 AM - 10:45 AM (EST) Breast Cancer Scientific Interest Group Meet-the-Expert Session
Celina Kleer, MD • University of Michigan 
"Understanding Breast Cancer: My Journey as a Physician Scientist"
10:45 AM - 11:30 AM (EST) Questions and Answers
Satdarshan (Paul) Monga

Liver Pathobiology Scientific Interest Group
Meet-the-Experts Session

Sponsored by the ASIP Liver Pathobiology Scientific Interest Group

Session Moderators:
Satdarshan (Paul) Monga, MD • University of Pittsburgh
Kari Nejak-Bowen, MBA, PhD • University of Pittsburgh

Kari Nejak-Bowen
10:00 AM - 10:30 AM (EST) David Cohen, MD, PhD • Weill Cornell Medicine
"NAFLD: Cellular and Molecular Basis and Therapies"
10:30 AM - 11:00 AM (EST) Jan Tchorz, PhD • Novartis Institutes
"Liver Homeostasis, Zonation and Repair"
11:00 AM - 11:30 AM (EST) Questions and Answers
11:30 AM - 1:00 PM (EST) Break (View the ePosters)
Patricia D'Amore

Plenary Session: Bench to Bedside: NOT Lost in Translation

Patricia D'Amore, PhD • Schepens Eye Research Institute/Harvard Medical School
Francis (Bill) Luscinskas, PhD • Brigham & Women's Hospital

Francis (Bill) Luscinskas
1:00 PM - 1:30 PM (EST)

Joan Miller, MD • Massachusetts Eye & Ear Infirmary
“From Bench to Bedside: The Development of Anti-VEGF Therapy in Ophthalmology”

The development and approval of anti-vascular endothelial growth factor (VEGF) drugs for retinal diseases has completely changed the field of ophthalmology—improving vision outcomes and quality of life for millions of people around the world. In this lecture, we will we will revisit the pathway to the successful development of anti-VEGF therapies and discuss the hurdles and strategies needed to move potential therapies from bench to bedside.

1:30 PM - 2:00 PM (EST)

Christina Lockwood, PhD, DABCC, DABMGG • University of Washington
New and Emerging Opportunities and Consideration for Cell-Free DNA in Laboratory Medicine

The earliest report of cell-free DNA in healthy individuals dates to the 1940s and it has been most widely adopted in medicine in assessing fetal risk of chromosomal abnormalities in pregnant women. In oncology, there are a variety of clinical applications for a minimally invasive blood test for DNA released from tumor cells. The increased adoption of targeted cancer therapies underscores the need to augment invasive tissue biopsies with alternative detection methods that rapidly monitor treatment response. In this lecture, we will review the clinical indications for cell-free DNA and discuss the opportunities and challenges associated with cell-free DNA testing in pregnancy and oncology.

2:00 PM - 2:30 PM (EST)

Mark Puder, MD, PhD • Boston Children's Hospital
Intestinal Failure Associated Liver Disease, A Laboratory and Clinical Approach

Many children are unable to tolerate or absorb nutrients and require intravenous nutrition (parenteral nutrition). Parenteral nutrition contains sugar, amino acids, lipids, vitamins and trace elements. This nutrition is life-saving, however up to 60% of infants develop intestinal failure associated liver disease (parenteral nutrition associated liver disease) that was responsible for 1.4% of all deaths in children age 4 years and under. This disease was one of the main indications for liver and multivisceral transplants in children. At the time, the actual component(s) of the parenteral nutrition producing the liver disease was unknown. We will discuss the laboratory experiments to understand the etiology (lipids) and the pathway to FDA approval of alternative lipid emulsions in treating this often fatal disease.

2:30 PM - 2:45 PM (EST) Questions and Answers
2:45 PM - 3:00 PM (EST) Break
Jennifer Sanders

Symposia: Not a Monolithic Disease: Cancer Heterogeneity and Precision Oncology

Jennifer Sanders, PhD • Brown University
Dipak Panigrahy, MD • Beth Israel Deaconess Medical Center

Session Description: Novel genetic and epigenetic changes in the tumor as well as the specific tissue microenvironment underlie the unique nature of tumor development, progression and response. Cancer therapy is challenging due to genetic heterogeneity of tumors, the diversity of pathways used by different tumors, and the relentless evolution of drug resistance. Nongenetic heterogeneity is also critical consideration as cells respond to broad, environmental perturbations and drug treatments. Big data technologies have expanded our abilities to characterize and model individual tumor and patient responses. In this symposium, we will discuss the contribution and mechanisms by which differences in the tumor and host genome, epigenome and tumor microenvironment regulate tumor evolution and individual patient response to therapy. We will also delve into how the knowledge generated by big data combined with artificial intelligence and machine learning approaches can lead to advances in more precise diagnostic and therapeutic options for patients.

Dipak Panigrahy
3:00 PM - 3:30 PM (EST) Laura van't Veer, PhD • University of California, San Francisco
“Matching Targeted Therapies to the Biology of Disease in Breast Cancer”
3:30 PM - 4:00 PM (EST) Simona Cristea, PhD • Harvard University
“Unravelling Subclonal Heterogeneity and Aggressive Disease States in Triple Negative Breast Cancer Through Single-Cell RNA-Seq"
4:00 PM - 4:15 PM (EST)

Anindya DuttaAbstract-Driven Short Talk
Anindya Dutta - "Hundreds ff Common Germline Variants Predict Cancer Progression In Thirty-Three Different Cancer Types And Will Be Useful For Precision Oncology"


4:15 PM - 4:30 PM (EST)

Abstract-Driven Short Talk
Kun Zhou - "A Novel Orally available Wnt-Pathway Inhibitor for the Treatment of Metastatic Cancers"


4:30 PM - 4:45 PM (EST)

Ethan LaRochelleAbstract-Driven Short Talk
Ethan LaRochelle - "Implementation of Next-Generation Sequencing Bioinformatics Pipeline for Solid Tumor Gene Panel"


4:45 PM - 5:00 PM (EST) Questions and Answers
James Stone

Symposia: And the Beat Goes On: New Wrinkles in Cardiovascular Pathophysiology

James Stone, MD, PhD • Massachusetts General Hospital
Traci Parry, PhD • University of North Carolina at Greensboro

Session Description: This symposium will cover two important and evolving topics in cardiovascular pathophysiology, the genetics of sudden death and the role of inflammation in atherosclerosis.  Sudden unexpected cardiac death strikes without warning, killing both young and old. While some genetic variants have long been associated with sudden cardiac death, the wider application of whole genome sequencing in those who experience sudden cardiac death is opening up new avenues for research into this phenomenon; but it is also creating complexities into understanding the true pathogenicity of newly identified genetic variants.  Atherosclerosis remains a leading cause of death world-wide. Through both animal modelling and human studies inflammation promoted by interleukin-1 has been identified as a key driver of this pervasive condition.  A detailed understanding of the inflammatory response in the vessel wall during atherogenesis offers the potential for the development of novel and selective approaches to treat this deadly condition. 

Traci Parry
3:00 PM - 3:30 PM (EST) Heidi Rehm, PhD • Broad Institute/Massachusetts General Hospital/Brigham and Women’s Hospital/Harvard Medical School
“Curating the Clinical Genome on a Global Scale”
3:30 PM - 4:00 PM (EST) Peter Libby, MD • Brigham & Women's Hospital and Harvard Medical School
“Interleukin-1 in Atherosclerosis: A Translational Journey”
4:00 PM - 4:15 PM (EST)

Sudarshan BhattacharjeeAbstract-Driven Short Talk
Sudarshan Bhattacharjee - "Role of Epsin and Dab2 in Trafficking of Vascular Endothelial Growth Factor Receptor During Angiogenesis"


4:15 PM - 4:30 PM (EST)

Sasha SmolgovskyAbstract-Driven Short Talk
Sasha Smolgovsky - "Reduced Hypertrophic Cardiac Remodeling and Preserved Diastolic Function in T Cell-Deficient Mice in a Novel Mouse Model of Heart Failure with Preserved Ejection Fraction"


4:30 PM - 4:45 PM (EST)

Abstract-Driven Short Talk
Francisco Carrillo-Salinas - "Cardiac Pressure Overload Induces Gut Dysbiosis That Promotes T Cell Activation and Maladaptive Remodeling Downregulating the Aryl Hydrocarbon Receptor Expression"


4:45 PM - 5:00 PM (EST) Questions and Answers
Andrew W. DuncanDaisy ShuChad Walesky

Navigating the Socialsphere: A How-to Guide for Promoting Your Scientific Career Online
Sponsored by the ASIP Committee for Career Development and Diversity


Andrew W. Duncan, PhD • University of Pittsburgh
Daisy Shu, PhD • Harvard University
Chad Walesky, PhD • Harvard University
Francisco Carrillo-Salinas, PhD • Tufts University
Marina Anastasiou, BS • Tufts University
Gina LaBorde • American Society for Investigative Pathology

Session Description: Let's celebrate the rapid rise of scientific content and scientists on social media, strategize for the future and become the scientific champion of your science needs by amplifying your research online.

Francisco Carrillo-SalinasMarina AnastasiouGina LaBorde
6:00 PM - 6:10 PM (EST) Welcome & Introductions
6:10 PM - 6:25 PM (EST) Daisy Shu, PhD • Harvard University
How to Get Started on Social Media and Build a Following
6:25 PM - 6:40 PM (EST) Eric Perkins, PhD • Addgene
Promoting Your Brand (of Science) on Social Media
6:40 PM - 6:55 PM (EST) Daniel Camarda, MS • Harvard University
Best Practices for Social Media Usage, an Institutional Perspective
7:00 PM - 7:30 PM (EST) Panel Discussions, Break-out Rooms

Break-out Room 1 - "Social Starters" (Beginning Users)
Break-out Room 2 - "Social Pros" (Intermediate & Advanced Users)

Thursday - November 12, 2020

8:00 AM - 9:00 AM (EST)

Trainee Advising Session

Morgan Preziosi, PhD • Chimeron Biotech
Transitioning from Academic Research to Biotech R&D
Non-academic and non-government research opportunities continue to expand at a rapid rate. Scientists are now employed in various commercial settings from small start-up biotech companies to large industrial operations. While the foundation for how research is conducted is the same between academic and commercial research settings, the objectives are often dramatically different. Likewise, the research environment and research teams will vary between these settings. This session will describe the experience of transitioning from academic research into the biotech setting, and will provide information on elements of training that will best equip an individual to pursue research in the biotech setting. This session will be of interest to undergraduates, graduate/medical students, or postdoctoral fellows.

9:00 AM - 10:00 AM (EST)

Trainee Advising Session

Veronica Contreras-Shannon, PhD • St. Mary's University
Summer Research Programs
Summer research programs are very important for undergraduates who plan to enter graduate school to pursue a PhD in some biomedical research discipline. For students who attend college at a research university, opportunities for summer research might be abundant. However, students attending smaller institutions lack this sort of on-campus research opportunities. Therefore, many larger institutions provide summer research programs to enable undergraduates to gain valuable experience before applying for or entering graduate school. This session will describe summer research opportunities and how students can access them. This session will be of primary interest to undergraduate students, but might also be of interest to graduate students or postdoctoral fellows who work in research laboratories that host summer students.

10:00 AM - 11:00 AM (EST)

Trainee Advising Session

Andrew Duncan, PhD • University of Pittsburgh
When and How to Find a Post-Doc Laboratory
Postdoctoral training represents a final critical element in the preparation of an individual for a career in research, whether in academics, government, or industry. The postdoctoral training experience builds on graduate training and provides an opportunity for an individual to gain experience and expertise in a specific research area or focused on a specific research topic. Therefore, the selection of a host laboratory and research mentor for the postdoctoral training period is critical. This session will provide guidelines for when and how to identify the right mentor and laboratory for postdoctoral training. This session will be of most interest to graduate students who anticipate looking for a postdoctoral research opportunity in the near future.

11:00 AM - 1:00 PM (EST)

Lunch Session: Pathology Career Pathway Networking
Sponsored by the ASIP Career Development and Diversity Committee and the ASIP Education Committee

Session Description: Seeking to transition into or learn more about the dynamic careers in the biotechnology industry? Thinking about the next steps in your pathology career? This networking session is designed to connect you with leading experts in the biotechnology field. Panelists were chosen from a vast array of companies (many local to the Boston area) and range from product sales and distribution to bench scientists to group leaders to company founders and CEOs.

This lunch session will function similar to a speed networking session where small groups will interact with the panelists for approximately 15 minutes in separate breakout rooms.  Feel free to ask questions or obtain career advice. This networking session is ideal for trainees at all levels including undergraduates, graduate students, post-doctoral fellows, residents, and junior faculty.

Zeev Gechtman, PhD
Product Manager

Mark Kieran, MD, PhD
Senior Director, Pediatric Oncology, Oncology Clinical Development
Bristol Myers Squibb

Morgan Preziosi, PhD
Chimeron Bio

Michelle Le Blanc, PhD
Scientist, Retinal Biology
Generation Bio

Jared Iacovelli, PhD
Associate Director, Exploratory Biology

Sumana Chintalapudi, PhD
Field Application Specialist
Bioinformatics Digital Insights

Randy Watnick, PhD
Co-Founder; Head, Scientific Advisory Board
Vigeo Therapeutics

Lindsay Wong
Associate Scientist II

Jeffrey Johnson, PhD
Vice President, Academic Relations
Cayman Chemical Company

Cassandra Rogers
Field Application Specialist – Cell Analysis

Marya Chaney, PhD
Clinical Director, Early Drug Development

Steven Pirie-Shepherd, PhD
Director, Oncology Translational Sciences-Tissue Morphology Group
Pfizer, Inc.

Joshua Judkins, PhD
Biosciences Account Manager/Global Lead LGBTA ERG
Thermo Fisher Scientific

Lorna Cryan, PhD
Senior Scientist
Cyteir Therapeutics

Plenary Session: Computational Pathology: Big Data, Big Ideas Translation

Jeffrey Golden, MD • Brigham & Women's Hospital
Lynn Bry, MD, PhD • Brigham & Women's Hospital

Session Description: Big data has referred to the means to acquire and analyze new, complex and multi-dimensional sources of information. Novel tools to extract meaning from ‘big data’ have the potential to drive substantive changes in clinical practice, from personalized diagnostics, prognostics and therapeutics to intelligent drug design, population surveillance/screening and the mining of the electronic health record. Successful integration of data analytics and data sciences within platforms for biomedical discovery are expanding further innovations and applications to patient care. 

In this symposium we will explore underlying principles of big data approaches, and the translation of findings to clinical applications. Discussions will explore three examples of integrated ‘big data’ and functional discovery approaches, (1) digital imaging and improved pathologic diagnosis, (2) pathogen and microbiome big data approaches to identify new therapeutic targets and implement better prevention methods for pathogens from C. difficile to COVID-19, and (3) single cell sequencing to define genomic and environmental drivers of cancer, and identify targets for new therapeutic approaches. These examples will provide insights into how computational pathology is developing the tools we will be using to care for patients in the future. 

1:00 PM - 1:30 PM (EST) Andrew Beck, MD, PhD • PathAI
AI and Pathology Imaging
1:30 PM - 2:00 PM (EST) Lynn Bry, MD, PhD • Harvard Medical School/Brigham and Women's Hospital
Microbiome and Applications of Big Data
2:00 PM - 2:30 PM (EST) Mario Suva, MD, PhD • Harvard Medical School/Massachusetts General Hospital/The Broad Institute of MIT
Dissecting Brain Tumors by Single-Cell Genomics
2:30 PM - 2:45 PM (EST) Questions and Answers
2:45 PM - 3:00 PM (EST) Break

Symposia: New Horizons for Neutrophils and Monocytes in Mucosal and Vascular Cell Biology

Francis (Bill) Luscinskas, PhD • Brigham & Women's Hospital
Asma Nusrat, MD • University of Michigan

Session Description: Monocytes and neutrophils play key roles in the pathogenesis of many diseases. Monocytes undergo a continuum of phenotypic and functional changes in response to inflammatory cues.  The first presentation identified mechanisms that drive monocyte to macrophage differentiation in glomerulonephritis, an autoimmune disease of the kidney. Leukocyte adhesion and migration requires rapid actin dynamics. The second presentation studied the function of the cortactin homologue HS1 in neutrophils using two different murine models: intravital microscopy of the inflamed cremaster microcirculation and experimental colitis.

3:00 PM - 3:30 PM (EST) Tanya Mayadas, PhD • Brigham and Women's Hospital
Molecular Control of Monocyte Maturation During Inflammation
3:30 PM - 4:00 PM (EST) Michael Schnoor, PhD • Centro de Investigacion y de Estudios (CINVESTAV) 
"The Actin-Binding Protein HS1 Regulates Neutrophil Recruitment Patterns During Inflammation"
4:00 PM - 4:15 PM (EST)

Veronica AzcutiaAbstract-Driven Short Talk
Veronica Azcutia - "Neutrophil Expressed CD47 Regulates CD11b/CD18-Dependent Neutrophil Transepithelial Migration in the Intestine In Vivo"


4:15 PM - 4:30 PM (EST)

Abstract-Driven Short Talk
Rachel Gao - "Bile Acids Modulate Colonic MAdCAM-1 Expression in a Murine Model of Combined Cholestasis and Colitis"


4:30 PM - 4:45 PM (EST)

Ruth WangAbstract-Driven Short Talk
Ruth Wang - "Butyrate Regulates the Actin-Binding Protein Synaptopodin to Promote Wound Healing and Intestinal Epithelial Barrier Function"


4:45 PM - 5:00 PM (EST) Questions and Answers
Gregory Tsongalis

Symposia: Molecular Diagnostics: The Liquid Biopsy

Gregory Tsongalis, PhD • Dartmouth-Hitchcock Health System
D. Hunter Best, PhD, FACMG • University of Utah

Session Description: This session will give an overview of the current applications of liquid biopsy to solid tumors. The liquid biopsy has been shown to be a surrogate for tissue biopsy in several scenarios and could be used more frequently to monitor response to therapy and disease progression. To date these applications seem very promising but liquid biopsy testing has yet to become routine practice in part due to the non-standardization of this technology and lack of clear clinical interpretation of low allelic frequency variants. This session will feature two invited speakers (Dr John Iafrate from Massachusetts General Hospital and Dr. Joshua Coleman from ARUP Laboratories), as well as several abstract-driven talks. Dr. Iafrate will discuss circulating tumor DNA and possible applications for detection of such in non-invasive cancer molecular diagnostics. Dr. Coleman will discuss the liquid biopsy and its value in detection of solid cancers. The abstract-driven talks will be based upon submitted research in the area of cancer molecular diagnostics.

D. Hunter Best
3:00 PM - 3:30 PM (EST) A. John Iafrate, MD • Massachusetts General Hospital
ctDNA: Practical Realities and Future Applications" 
3:30 PM - 4:00 PM (EST) Joshua F. Coleman, MD • University of Utah Health
"Liquid Biopsy: Emerging Applications for Solid Tumors"
4:00 PM - 4:15 PM (EST)

Abstract-Driven Short Talk
Sophie Deharvengt - "Sequencing the Novel Coronavirus Using the Ion AmpliSeq™ SARS-CoV-2 Research Panel"


4:15 PM - 4:30 PM (EST)

Imad TarhoniAbstract-Driven Short Talk
Imad Tarhoni - "Novel Autoantibodies Biomarkers Panel Test to Prognosticate Clinical Outcomes in Advanced-Stage NSCLC Patients Receiving Anti PD-1/-L1 Immunotherapy"


4:30 PM - 4:45 PM (EST)

Ourania ParraAbstract-Driven Short Talk
Ourania Parra - "Molecular Profiling of Two Unclassified Primary Bone and Soft Tissue Tumors"


4:45 PM - 5:00 PM (EST) Questions and Answers

Friday - November 13, 2020

8:00 AM - 9:00 AM (EST)

Trainee Advising Session

Richard N. Mitchell, MD, PhD • Brigham & Women's Hospital
What’s up with an MD/PhD and Am I Competitive?
Individuals with both MD and PhD training have the opportunity to pursue careers that involve both clinical service and biomedical research, and/or are well prepared to pursue research that utilizes basic science research methods and approaches to address important problems related to human health and disease. Some people achieve MD-PhD training through separate programs and others through medical scientist training programs. In either case, individuals pursuing both degrees need to be competitive for acceptance into both medical school and graduate school. This session will provide guidelines for how individuals can prepare to pursue MD-PhD training and associated career opportunities. This session will be of interest to undergraduates, graduate/medical students, or postdoctoral fellows.

9:00 AM - 10:00 AM (EST)

Trainee Advising Session

Patricia D’Amore, PhD • Schepens Eye Research Institute/Harvard Medical School
How to Get the Most From Mentoring Relationships
Everyone needs good mentors to succeed in training and careers. The research mentor is particularly important to undergraduate, graduate student, and postdoctoral trainees who are learning to perform basic science research, gaining experience with research methods and approaches, and developing expertise in a specific research area. Mentors keep trainees focused and on-track. However, not all mentors are created equally and so there is a need to understand what to expect from mentors and to have strategies in place to ensure excellent mentoring, even if that requires multiple mentors. This session will be of interest to undergraduates, graduate/medical students, or postdoctoral fellows.

10:00 AM - 12:00 PM (EST)

Panel Discussions - COVID-19 Updates from Frontline Experts

Moderator: Chhavi Chauhan, PhD, ELS
American Society for Investigative Pathology


James Musser, MD, PhD
Houston Methodist Hospital
Expertise: Convalescent Plasma Therapy

L. Maximilian Buja, MD
The University of Texas System/Texas Heart Institute
Expertise: COVID-19 Autopsy, Associated Cardiac Pathobiology and underlying mechanisms, COVID-19 co-morbidities

Helen Fernandes, PhD
Columbia University
Expertise: Molecular Testing for COVID-19

Richard S. Vander Heide, MD, PhD, MBA
LSU Health School of Medicine
Expertise: COVID-19 Autopsy, Associated Cardiac Pathobiology and Underlying Mechanisms, COVID-19 Co-Morbidities

Jody E. Hooper, MD
Johns Hopkins Hospital
Expertise: COVID-19 Autopsy, Cancer Pathobiology and Underlying Mechanisms, COVID-19 Co-Morbidities

Charles Parkos, MD, PhD
University of Michigan
Expertise: Serological Testing for COVID-19

Elizabeth Whitley

Plenary Session: Architectural Models of Disease: Rendering Complexity on a Small Scale

Elizabeth Whitley, DVM, PhD • University of Texas MD Anderson Cancer Center
Arlin Rogers, DVM, PhD • Alnylam Pharmaceuticals

Session Description: Experimental models allow empirical research in physiologic and pathophysiologic processes. In this symposium, we highlight innovative models that deliver high levels of complexity that allow of dissection and modification of complicated, interactive biological systems, while also providing measures of efficiency and affordability and addressing the three “Rs” tenet of animal modeling (Replacement, Reduction, and Refinement). The first presentation of this symposium will focus on the emerging use of Zebrafish as vertebrate models for metabolic and neoplastic diseases of the liver and pancreas. The second presentation will delve into molecular mechanisms that modify the hallmark traits of aging and result in vast differences in lifespan across rodent species. The third presentation will describe stem cell engineering strategies for in vitro manufacture of mature, functional populations of blood components for preclinical studies and eventual clinical use. 

Arlin Rogers
1:00 PM - 1:30 PM (EST) Wolfram Goessling, MD, PhD • Harvard Stem Cell Institute
“Liver Regeneration: Fate and Function”
1:30 PM - 2:00 PM (EST) Vera Gorbunova, PhD • University of Rochester
Mechanisms of Longevity in Naked Mole Rats and Other Long-Lived Rodents
2:00 PM - 2:30 PM (EST) George Daley, MD, PhD • Harvard Medical School/Children's Hospital Boston
Blood From a Petri Dish
2:30 PM - 2:45 PM (EST) Questions and Answers
2:45 PM - 3:00 PM (EST) Break
Pilar Alcaide

Symposia: Host-Microbial Interactions at the Mucosal Surfaces

Pilar Alcaide, PhD • Tufts University School of Medicine
Andrei Ivanov, PhD • Cleveland Clinic Foundation

Session Description: Mucosal epithelia create critical interfaces and protective barriers to interact with commensal microbes and prevent pathogen invasion. This symposium will present recent advances in understanding the mechanisms that regulate host-microbial cross-talk at different mucosal surfaces. The first talk will be dedicated to local immune mechanisms that protect against HIV in the female genital tract, with specific focus on neutrophils and neutrophil extracellular traps. The second talk will be focused on the intestinal mucosa and will describe the roles of natural killer T (NKT) cells in regulating gut microbial commensalism and response to pathogens.  Age dependent and microbiome dependent mechanisms of NKT cell regulation will also be discussed. 

Andrei Ivanov
3:00 PM - 3:30 PM (EST) Marta Rodriguez-Garcia, MD, PhD • Tufts University School of Medicine
“The Role of Neutrophils in HIV Prevention in the Female Genital Tract”
3:30 PM - 4:00 PM (EST) Richard "Rick" Blumberg, MD • Brigham and Women's Hospital/Harvard
“NKT Cells at the Mucosal Interface
4:00 AM - 4:15 PM (EST)

Abstract-Driven Short Talk
Melinda Engevik - "Fusobacterium Nucleatum Metabolites and Outer Membrane Vesicles Drive Intestinal Inflammation in Vitro and In Vivo"


4:15 AM - 4:30 PM (EST)

Abstract-Driven Short Talk
Joseph Lee - "Microbiota-sourced Purines Promote Gut Mucosal Wound Healing and Barrier Function"


4:30 AM - 4:45 PM (EST)

Elena FeketeAbstract-Driven Short Talk
Elena Fekete - "Mucosal Defenses Against Giardia duodenalis: A Role for PAR2"


4:45 AM - 5:00 PM (EST) Questions and Answers
Diane Bielenberg

Symposia: Lymphatic Biology, Obesity, and Beyond

Diane Bielenberg, PhD • Boston Children's Hospital/Harvard Medical School
Yang Lee, PhD, MS, BS • Boston Children's Hospital/Harvard Medical School

Session Description: The lymphatic vascular system is a unidirectional conduit to recycle protein-rich lymph in the interstitial space back to the venous system. Lymphatics regulate interstitial fluid volumes to prevent edema, transport antigens to lymph nodes, facilitate immune cell traffic to and from lymph nodes, and absorb dietary fats in the intestines. The structure and morphology of lymphatic vessels and the cell-cell junctions present between lymphatic endothelial cells are crucial to vessel integrity and proper lymphatic function. Despite the well-established role that lacteals play in the absorption of dietary fat in the intestines, the role of lymphatic junctional remodeling and its impact on obesity and inflammatory diseases such as metabolic syndrome have only recently been recognized. Presentations in this session will discuss mechanisms regulating lymphatic function in health and disease and explore the bidirectional relationship between obesity and the lymphatic system.

Yang Lee
3:00 PM - 3:30 PM (EST) Hong Chen, PhD • Harvard Medical School/Boston Children's Hospital
“Mechanisms of Foxc2-Mediated Regulation of Lymphatic Function in Metabolic Diseases”
3:30 PM - 4:00 PM (EST) Anne Eichmann, PhD • Yale University School of Medicine
“Lacteal Junctions as Regulators of Plasma Lipid Uptake and Obesity”
4:00 PM - 4:15 PM (EST)

Abstract-Driven Short Talk
Michael Thompson - "Maternal Obesogenic Diet Exposure Leads to Microbiome Associated Changes in Bile Acid Metabolism and Increased Cholestatic Liver Injury in Offspring"


4:15 PM - 4:30 PM (EST)

Abstract-Driven Short Talk
Erik Butcher - "A Semi-Automated Multiparametric Pipeline for Mitochondrial Segmentation and Quantification to Evaluate Metabolic Dysregulation"


4:30 PM - 4:45 PM (EST)

Abstract-Driven Short Talk
Xichun Li - "Therapeutic Knockdown of RIPK1 Pathway Halts the Progression of Diet-Induced Obesity and Improves Insulin Resistance"


4:45 PM - 5:00 PM (EST) Questions and Answers
5:00 PM - 5:30 PM (EST) Closing Remarks